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  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
  • Pre-filled Flush Syringe Filling Production Line
Products

Pre-filled Flush Syringe Filling Production Line

Leggenda specializes in prefilled syringe filling systems, delivering high-standard automated solutions for the medical consumables and biopharmaceutical industries. Our Pre-filled Syringe Flushing Filling Lines is engineered for the large-scale production of 0.9% normal saline, heparin lock flush solutions, and medical gels. It integrates nested tray loading, high-precision filling, automated stoppering, rod screwing, labeling, and final tray packing into a comprehensive aseptic process.

Designed to meet the dual demands of efficiency and compliance, this line utilizes a full servo-drive system and high-precision ceramic pumps. Operating under ISO Class 5 (Grade A) laminar flow protection, it achieves an industry-leading filling accuracy of ±0.5%. The entire system adheres to cGMP regulations and FDA standards, ensuring absolute product sterility and dosage precision.

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Description

 

Key Highlights:

 

High-Speed Output: Available in 4-nozzle, 6-nozzle, and 8-nozzle configurations, with a capacity range of 8,000 to 15,000 syringes per hour.

 

Flexible Manufacturing:​ Supports rapid format changes for 3mL, 5mL, and 10mL syringes, significantly boosting OEE (Overall Equipment Effectiveness).

 

Regulatory Assurance:​ Features a fully enclosed design and data traceability systems to facilitate smooth regulatory audits.

 

Drawing on in-depth technical know-how and a wealth of successfully implemented projects across clinical care, hemodialysis and biopharmaceuticals, Leggenda provides proven, mature solutions that reduce operational costs and accelerate your time-to-market.

Within the medical consumables sector, manufacturers face the ongoing challenge of balancing production efficiency and cost control while maintaining aseptic compliance. The Pre-filled Syringe Flushing Solution Filling Line by Leggenda is engineered to address this requirement reliably.

Integrating high-precision filling, automated stoppering, rod screwing, labeling, and final tray packing into a single, unified system, this Pre-filled Syringe Filling Line is purpose-built for the mass production of normal saline and heparin lock flush solutions. Designed in accordance with GMP and FDA regulations, the flushing solution filling system supports consistent product sterility and reliable batch-to-batch quality across all production run.


1. Precision Filling: Consistency You Can Measure

In medical filling, consistency is currency. Our servo-driven pumps maintain a steady ±0.5% accuracy across runs. This tight control minimizes costly overfills and ensures every syringe meets pharmacopeia standards—helping you pass batch releases with ease.

 

2. Modular Design: Keep Your Line Moving

Our modular design makes format changes between 3mL, 5mL, and 10mL feel effortless. Fewer tools, fewer steps, and less downtime mean you can respond to urgent orders without disrupting your entire schedule.

 

​3. Laminar Flow: Protecting Product Integrity

Critical stations operate within ISO Class 5 (Class 100) laminar flow. Rather than just meeting standards, we provide the controlled environment your sensitive flushing solutions need to maintain integrity from fill to finish.

 

4. 316L Contact Parts: Built for the Long Run

All product-contact parts are crafted from 316L stainless steel. This isn't just about corrosion resistance—it’s about maintaining surface smoothness to prevent particle generation and ensure easy cleaning, protecting your investment for years to come.

 

5. Smart Flexibility: Adapt to Market Needs

Whether you’re running saline, heparinized saline, or other flushing formulations, the system adapts smoothly. This flexibility allows you to diversify your portfolio and meet evolving clinical demands without investing in new hardware.

 

6. Batch Records: Always Audit-Ready

With comprehensive electronic batch records and seamless MES integration, your data is organized and accessible. When auditors arrive, you’ll have the clarity and documentation to support your process—without the last-minute scramble.


Mass production of pre-filled flushing syringes for hospital CSSD use

Consumables manufacturing for IV cannula, PICC, and CVC catheter maintenance

Upgrading sterile liquid filling lines to meet higher cleanliness standards


FAQ

  • What products are your filling lines designed for?

    We offer two dedicated lines: Vacuum Filling Lines for small-volume sterile injectables (0.2–20 mL), including biologics, vaccines, and aesthetic formulations (HA series, PDRN, collagen, Gel, PLLA, Hydroxyapatite, Cross‑linked products, Mesotherapy injectable series, etc.), and Catheter Flush Syringe Lines for high-throughput production of saline and heparin flush syringes. For specific formulation compatibility.

  • Are your machines GMP and FDA compliant?

    All equipment is designed in compliance with GMP specifications and can be implemented with reference to relevant FDA general standards. Our quality management system is certified to ISO 9001 and CE. We provide complete documentation support to assist customers in completing the validation procedures.

  • Can you customize lines for our facility?

    Yes. Our modular lines support adjustable head counts, multiple container formats (PFS, cartridges, vials), and flexible layouts (linear, L-shape, U-shape) to fit your cleanroom.

  • What is the typical lead time?

    Standard lead time ranges from 16 to 28 weeks depending on configuration and current order backlog. Expedited options may be discussed for urgent projects.

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About Us
Leggenda (Shanghai) Technology Co., Ltd.

Leggenda (Shanghai) Technology Co., Ltd. was founded in 2019 and is headquartered in Shanghai. It is a supplier of automated pharmaceutical equipment systems and related services, serving pharmaceutical enterprises with products including small-volume pre-filled water syringes.

With a mission to deliver professional services for the pharmaceutical industry, Leggenda Technology prioritizes quality-driven development. Through continuous innovation, it safeguards pharmaceutical production with safer, greener and more advanced professional technologies.

The company consistently upholds the product philosophy of technological innovation and quality first, and attaches great importance to talent training and development. It keeps increasing R&D investment for new products. Within just a few years, the company has filed for and obtained multiple patents. It has finished the product development of high-speed production lines for pre-filled flush syringes, delivering high-speed and turnkey solutions for numerous clients. We are a pioneer in the technical field of vacuum filling and vacuum stoppering for high-viscosity products.

In response to the rapid growth of the pharmaceutical industry and the complex, unique features of production processes, the company vigorously develops core products and concentrates on the R&D of syringe filling equipment. At present, technical staff account for approximately 80% of its total workforce. Most are design and technical engineers with over 10 years of hands-on experience in the pharmaceutical equipment sector.

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