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  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
  • Syringe Vacuum Filling & Stoppering Machine
Products

Syringe Vacuum Filling & Stoppering Machine

This vacuum filling machine is specially designed for high-viscosity medical aesthetic gels and sterile injectable preparations. It adopts a full-servo precise metering design and complies with cGMP production specifications throughout the whole process. The machine can automatically complete full-process procedures including feeding, filling, vacuum stoppering and so on, effectively addressing industry pain points of traditional filling equipment such as excessive bubbles, poor sealing performance, and delamination and damage of high-viscosity materials. It can flexibly adapt to scenarios including R&D pilot tests, small and medium-batch sampling and large-scale flexible production, and meet the personalized and differentiated production demands of pharmaceutical factories, medical aesthetic preparation manufacturers and CDMO/CMO contract manufacturing organizations.

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Description

Key Features

 

Ceramic Plunger Pump

±0.5% accuracy, wear- and corrosion-resistant; ideal for high-viscosity HA, gels, biologics.

 

Full Servo Control

Siemens PLC + HMI, recipe management, 21 CFR Part 11-ready audit trail, multi-sensor alarms.

 

cGMP-Compliant Construction

316L stainless steel contact parts, medical-grade silicone, capsule filters, sanitary diaphragm valves.

 

Quick Format Changeover

Applicable to 0.2 / 1ml Long / 2.25 / 3 / 5 / 10 / 20 mL PFS

 

Flexible Configuration

Integrated laminar flow hood enables high-standard aseptic production.

Technical Data

Filling Mode

Ceramic Plunger Pump

 

Filling Accuracy

±0.5% （according to drug properties)

 

Design Production Capacity

1 head

≥800 pcs/h

2 head

≥1500 pcs/h

5 head

≥4500 pcs/h

10 head

≥8000 pcs/h

Filling & Stopper Vacuum Adjustment

0~50Kpa

 

Stopper Qualification Rate

≥99.9%

 

Applicable Equipment Specifications

0.2 ml/ 0.5ml/1 ml long /1-3 ml /5 ml /10 ml /20 ml

 

Equipment Noise

≤70 dB

 

Power Supply And Power

380v 50Hz

Applications

 

icon01   Biologics & Vaccines filling

icon02   Hyaluronic Acid & Dermal Fillers

icon06   Insulin & GLP-1 Injections filling

icon04   Ophthalmic & Veterinary Injectables filling

 

Discuss your process requirements with our engineering team.



FAQ

  • What products are your filling lines designed for?

    We offer two dedicated lines: Vacuum Filling Lines for small-volume sterile injectables (0.2–20 mL), including biologics, vaccines, and aesthetic formulations (HA series, PDRN, collagen, Gel, PLLA, Hydroxyapatite, Cross‑linked products, Mesotherapy injectable series, etc.), and Catheter Flush Syringe Lines for high-throughput production of saline and heparin flush syringes. For specific formulation compatibility.

  • Are your machines GMP and FDA compliant?

    All equipment is designed in compliance with GMP specifications and can be implemented with reference to relevant FDA general standards. Our quality management system is certified to ISO 9001 and CE. We provide complete documentation support to assist customers in completing the validation procedures.

  • Can you customize lines for our facility?

    Yes. Our modular lines support adjustable head counts, multiple container formats (PFS, cartridges, vials), and flexible layouts (linear, L-shape, U-shape) to fit your cleanroom.

  • What is the typical lead time?

    Standard lead time ranges from 16 to 28 weeks depending on configuration and current order backlog. Expedited options may be discussed for urgent projects.

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About Us
Leggenda (Shanghai) Technology Co., Ltd.

Leggenda (Shanghai) Technology Co., Ltd. was founded in 2019 and is headquartered in Shanghai. It is a supplier of automated pharmaceutical equipment systems and related services, serving pharmaceutical enterprises with products including small-volume pre-filled water syringes.

With a mission to deliver professional services for the pharmaceutical industry, Leggenda Technology prioritizes quality-driven development. Through continuous innovation, it safeguards pharmaceutical production with safer, greener and more advanced professional technologies.

The company consistently upholds the product philosophy of technological innovation and quality first, and attaches great importance to talent training and development. It keeps increasing R&D investment for new products. Within just a few years, the company has filed for and obtained multiple patents. It has finished the product development of high-speed production lines for pre-filled flush syringes, delivering high-speed and turnkey solutions for numerous clients. We are a pioneer in the technical field of vacuum filling and vacuum stoppering for high-viscosity products.

In response to the rapid growth of the pharmaceutical industry and the complex, unique features of production processes, the company vigorously develops core products and concentrates on the R&D of syringe filling equipment. At present, technical staff account for approximately 80% of its total workforce. Most are design and technical engineers with over 10 years of hands-on experience in the pharmaceutical equipment sector.

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