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Pre-filled Syringe Vacuum Filling & Stoppering Line
Leggenda specializes in pre-filled syringe vacuum filling technology, providing automated filling and stoppering solutions for biologics, vaccines, and aesthetic injectable products. The system features an integrated filling and stoppering design. Through a controlled vacuum environment, it reduces residual microbubbles and, combined with full servo-driven ceramic piston pumps, delivers stable and precise liquid dosing. The equipment is compatible with pre-filled syringes, cartridges, and vials.
 
  • Pharmaceutical

    • icon01 Biologics
    • icon02 Vaccines
    • icon03 Injectable Drugs
  • Aesthetic

    • icon04Hyaluronic Acid
    • icon01Collagen
    • icon05PLLA Microspheres
    • icon06Cross-linked Gel
    • icon07PDRN Solutions

Workflow

  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • Leggenda (Shanghai) Technology Co., Ltd.
  • 01 Bag Unpacking Station

    Remove outer pouch of syringe nest tub at this station
    01 Bag Unpacking Station
  • 02 Tub Conveying Station

    Convey nest tub along production line steadily and safely forward
    02 Tub Conveying Station
  • 02-1 Conveying to Heating Station

    Transfer nest tub to heating work station for peeling prep
    02-1 Conveying to Heating Station
  • 03 Heating Station

    Heat packaging to loosen tyvek lid for easy paper removal
    03 Heating Station
  • 04 Vacuum Suction & Tyvek Removal Station

    Vacuum suck to peel off tyvek cover from nest tub
    04 Vacuum Suction & Tyvek Removal Station
  • 05 Syringe Exposure Station

    Expose glass syringes after removing sterile tyvek pack material fully
    05 Syringe Exposure Station
  • 06 Gripping / Pick-up Station

    Grip syringes securely in preparation for liquid filling process ahead
    06 Gripping / Pick-up Station
  • 07 Filling & Vacuum Stoppering Station

    Fill liquid and apply vacuum stopper on glass pre-filled syringes
    07 Filling & Vacuum Stoppering Station
  • 08 Re-nesting Station after Filling

    Return filled syringes back into nest tub after filling completion
    08 Re-nesting Station after Filling

Specification

 

Parameter Performance
Filling Accuracy ±0.5%
Filling Technology Vacuum Filling
Container Compatibility Pre-filled Syringes / Cartridges / Vials
Filling Volume Range 0.2 mL – 20 mL
Syringe Format 1 mL – 20 mL
Drive System Full Servo Drive
Pump Type Ceramic Piston Pump
Product Contact Material SUS316L Stainless Steel
Design Standard cGMP Compliant
FAQ
  • Q.Can formulations with microspheres or suspended particles be vacuum-filled?

    A: Yes, our ceramic plunger pump systems handle particle-loaded formulations including PLLA and similar microsphere products. For detailed technical discussion, please leave your contact information and our engineering team will get in touch.

  • Q: What viscosity range can this machine handle?

    The standard ceramic plunger pump configuration reliably handles up to 80,000 mPa·s (e.g., HA gels, collagen, PLLA suspensions). For ultra-high-viscosity formulations in the 100,000–1,000,000 mPa·s class — such as paste-grade dermal filler bases, high-solids hydrogel precursors, and dental or resin pastes — we have successfully run trials and customer samples at approximately 1,000,000 mPa·s. At this viscosity level the product behaves as a thixotropic semi-solid rather than a free-flowing liquid; throughput decreases accordingly, and we always recommend sample validation with your actual formulation.